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Arouse Nasal Spray (PT-141 + Oxytocin)

£123.63

For optimal stability and integrity, we recommend reconstituting all peptides with bacteriostatic water, as reliability cannot be guaranteed with alternative solutions.

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Description

What is Arouse Nasal Spray (PT-141 + Oxytocin)?

Combining PT-141 and oxytocin in a nasal spray offers a convenient, rapid-acting, and potentially synergistic solution for potentially enhancing sexual arousal, desire, and emotional bonding and reducing anxiety.

Arouse Nasal Spray (PT-141 + Oxytocin) consists of two compounds:

The ingredients of Arouse spray include 5 mg of PT-141 and 5 mg of oxytocin, for a total of 10 mg overall and 0.1 mg in each spray.

What is PT-141?

Bremelanotide, formerly PT-141, is a synthetic alpha-MSH peptide analog. These receptors control hunger, energy homeostasis, and sexual behavior.[R] The cyclic heptapeptide structure of PT-141 makes it stable and bioactive, affecting several receptors. Melanocortin analogs like PT-141 resemble natural melanocortins, which play many roles in the body.[R]

PT-141
CAS189691-06-3
Molar Mass1025.182 g/mol
Chemical FormulaC50H68N14O10
IUPAC Name(3S,6S,9R,12S,15S,23S)-15-[(N-Acetyl-L-norleucyl)amino]-9-benzyl-6-{3-[(diaminomethylidene)amino]propyl}-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexaoxo-1,4,7,10,13,18-hexaazacyclotricosane-23-carboxylic acid

How does PT-141 or bremelanotide work?

PT-141 works by activating specific melanocortin receptors- namely, MC1R, MC3R, and MC4R- located in the hypothalamus, a brain region integral to sexual arousal. Research using PT-141 administration in rat models has shown that it helps stimulate these receptors to cause penile erections. This hypothalamic activation emphasizes the function of melanocortin receptors in controlling sexual responses and the therapeutic potential of PT-141 for treating sexual dysfunction.[R]

Melanocortin receptors (MCRs) regulate sexual function, pigmentation, energy balance, and inflammation. These diverse functions make the MCR family a research focus. The melanocortin-4 receptor (MC4R) is essential to sexual function, as its activation can affect sexual arousal.[R]

PT-141 Investigations

  • PT-141 for women may potentially enhance sexual arousal and desire in premenopausal test subjects[R]
  • Potential methods of treating erectile dysfunction [R][R][R]
  • Bremelanotide for male subjects may induce sexual desire [R]

Safety and Side Effects

PT 141’s most common side effects are nausea, vomiting, injection site reactions, flushing, and headache, according to the FDA. About 40% of the research study test subjects had nausea. [R]

What is Oxytocin?

Oxytocin
CAS50-56-6
Molar M1007.19 g/mol
Chemical FormulaC43H66N12O12S2
IUPAC Name1-({(4R,7S,10S,13S,16S,19R)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-16-(4-hydroxybenzyl)-13-[(1S)-1-methylpropyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosan-4-yl}carbonyl)-L-prolyl-L-leucylglycinamide

In 1996, Sir Henry Dale discovered that human posterior pituitary gland extracts may contract a pregnant cat’s uterus. Sir Henry Dale coined the word ” Oxytocin in Greek, meaning “swift birth.” [R]. Nine amino acids constitute OT, a peptide hormone the hypothalamus generates, which regulates heart rate, blood pressure, and digestion. The posterior pituitary gland releases this hormone.

Oxytocin regulates childbirth, lactation, and maternal bonding. It aids labor contractions, nursing, and mother-child bonding [R]. It also affects sexual desire, romantic connections, and social relationships. A 2012 study indicated that OT, “the love hormone,” was higher in new lovers than in singles, emphasizing its importance in early romantic partnerships[R].

How does Oxytocin work?

Men and women respond to oxytocin differently, and both genders use it extensively in reproductive activities. During labor and delivery, oxytocin causes the uterine muscles to contract, which helps mothers deliver their babies more easily. It induces a breast tissue contraction postpartum, facilitating lactation by encouraging milk ejection [R]. Surprisingly, oxytocin functions in a positive feedback loop, meaning that increased concentrations cause more significant release, as seen during labor when uterine contractions raise oxytocin levels even further [R].

Oxytocin affects the reproductive system in males as well. It may facilitate sperm movement by stimulating the smooth muscles in the male reproductive system. Furthermore, oxytocin may have brain effects that influence social bonding and sexual behavior. The dual roles that oxytocin plays in peripheral reproductive activities and central behavior regulation are highlighted by these central effects [R]

Oxytocin Investigations

  • May reduce the heart rate and blood pressure of premenopausal women[R]
  • May potentially induce sexual arousal and orgasm [R]
  • May increase in trusting behavior[R]
  • May induce penile erection[R]
  • It may regulate weight, insulin secretion, and insulin sensitivity.[R]

FAQ

Is Arouse Spray (PT-141 + Oxytocin) safe?

In addition to a lack of consistent evidence of direct benefits, the potential long-term effects of PT-141 + Oxytocin Stack still need to be discovered. Purerawz sells Arouse Spray for research purposes only, not as an oxytocin supplement or peptide for sex drive. The data presented rely solely on scientific studies for reference purposes and should not be taken as dietary supplements.

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